BIOCHEMISTRY

Atherosclerosis and Cardiac Markers (lectures) - by K D Mehta

 

ENTEROHEPATIC CIRCULATION

 

Factors affecting cholesterol balance at cellular level

 

Primary disorders of plasma lipoproteins (dyslipoproteinemias)

 

Mr Gurung

 

Mr Shrestha
He is a 61-year-old retired civil servant who lives alone in a rural setting following the death of his wife 2 years ago. He walks his two dogs at least twice a day; he drinks wine in moderation. His elder brother died of a stroke 5 years ago.
Clinical examination shows that he is not overweight, has a normal Blood pressure but has some slightly yellow patches in the skin.
 He is 60 years old, works long hours each week in running his own ‘oneman business; he often drives long distances from his home to attend meetings with clients. He has been divorced twice and now lives alone. Any free time he has is usually spent watching TV; he admits to consuming a bottle of whisky every week and often eats convenience foods.
Examination revealed a slightly high blood pressure and calculations based on his height and weight showed a moderate degree of obesity (body mass index, BMI 27 kg/m2, normal 25).

 

Lipid Profile Status
ATHEROMA FORMATION

 

Potential Mechanism by which oxidized forms of LDL (oxLDL) may be Atherogenic

- Products of oxLDL are chemotactic for circulating monocyte, T- lymphocyte and inhibit the motility of macrophage.

- Are Cytotoxic

- Can alter genes expression of neighboring arterial walls

- More susceptible to aggregation enhanced Macropage uptake

- Can adversely alter coagulation pathways

- Can induce proinflamatry bens and their products